Neuroblastoma: Ornithine decarboxylase and polyamines are novel targets for therapeutic intervention

2023-08-23T10:46:38-04:00March 12th, 2012|

Bachmann AS, Geerts D, Saulnier Sholler G: Neuroblastoma: Ornithine decarboxylase and polyamines are novel targets for therapeutic intervention, In: Pediatric Cancer, Volume 1, Neuroblastoma: Diagnosis, Therapy, and Prognosis, Ed. Hayat MA, Springer, Heidelberg, Germany, 2012

AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport

2023-08-23T10:40:21-04:00March 2nd, 2012|

Samal K, Zhao P, Kendzicky A, Yco LP, McClung H, Gerner E, Burns M, Bachmann AS, Saulnier Sholler G. AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport.  Int J Cancer. 2013 Mar 2. doi: 10.1002/ijc.28139. [Epub ahead of print]

Oral RKS262 Reduces Tumor Burden in a Neuroblastoma (NB) Xenograft Animal Model and Mediates Cytotoxicity through SAPK/JNK and ROS Activation in Vitro

2023-08-23T10:36:32-04:00February 12th, 2011|

Singh R, Dorf L, DeMartino A, Illenye S, Koto K, Ashikaga T, Kwang Kim K, Brard L, Saulnier Sholler G. Oral RKS262 Reduces Tumor Burden in a Neuroblastoma (NB) Xenograft Animal Model and Mediates Cytotoxicity through SAPK/JNK and ROS Activation in Vitro. Cancer Biol Ther. 2011, 11:12, 1-10.

Chemotherapeutic effect of calcidiol derivative B3CD in a neuroblastoma xenograft model. Chem Biol Drug

2023-08-23T10:24:48-04:00May 12th, 2010|

Lange TS, Zou Y, Singh RK, Kim KK, Kristjansdottir K, Sholler GL, Brard L. Chemotherapeutic effect of calcidiol derivative B3CD in a neuroblastoma xenograft model. Chem Biol Drug Des. 2010 Aug;76(2):164-73. doi: 10.1111/j.1747-0285.2010.00988.x. Epub 2010 May 11. PubMed PMID: 20492445; PubMed Central PMCID: PMC3024052. (6 citations)

Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells

2023-08-23T10:22:44-04:00February 12th, 2009|

Brard L, Singh RK, Kim KK, Lange TS, Saulnier Sholler G Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells.  Drug Des Devel Ther. 2009 Feb 6;2:61-9.

Effect of Indole Ethyl Isothiocyanates on Proliferation, Apoptosis and MAPK Signaling in Neuroblastoma Cell Lines

2023-08-23T10:20:58-04:00August 12th, 2007|

Singh R, Lange TS, Kim K, Zou Y, Lieb C, Saulnier Sholler G, Brard L. Effect of Indole Ethyl Isothiocyanates on Proliferation, Apoptosis and MAPK Signaling in Neuroblastoma Cell Lines. Bioorg Med Chem Lett. 2007 17(21):5846-5852.

Anti-proliferative and Pro-apoptotic Properties of 3-Bromoacetoxy Calcidiol (B3CD) in High-Risk Neuroblastoma

2023-08-23T10:07:58-04:00July 12th, 2007|

Lange TS, Singh RK, Kim K, Zou Y, Kalkunte S, Saulnier Sholler G, Swamy N, Brard L*. Anti-proliferative and Pro-apoptotic Properties of 3-Bromoacetoxy Calcidiol (B3CD) in High-Risk Neuroblastoma. Chem Biol Drug Des. 2007 70:302-310

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