Dr. Bredlau is currently the Director of the Pediatric Brain Tumor Program at the Medical University of South Carolina (MUSC). She is an Assistant Professor at MUSC, as well. Dr. Bredlau’s passion is in developing novel therapeutic options for children with incurable cancers. As such, she is actively involved in the Beat Childhood Cancer clinical trials and is co-Principal Investigator on a phase I/II trial investigating a placental growth factor inhibitor for medulloblastoma and other aggressive childhood cancers. Dr. Bredlau also works with many scientific laboratories to help guide the science at the bench-side toward pediatric cancers.
AL Bredlau, JW Semple, GB Segel. “Management of Immune Thrombocytopenic Purpura in Children: Potential Role of Novel Agents” Pediatric Drugs, 2011; 13(4): pp. 213-223. PMID: 21692546.
AL Bredlau, LS Constine, HJ Silberstein, MT Milano, DN Korones. “Incidental brain lesions in children: to treat or not to treat?” Journal of NeuroOncology, 2012 Feb; 106(3):589-94. PMID: 21853423.
AL Bredlau, MP McDermott, HR Adams, RH Dworkin, C Venuto, SG Fisher, JG Dolan, DN Korones. “Oral Ketamine for Children with Chronic Pain: A Pilot Phase 1 Study” Journal of Pediatrics, 2013 Jul;163(1):194-200.e1. PMID: 23403253.
AL Bredlau, R Thakur, DN Korones, RH Dworkin. “Ketamine for pain in adults and children with cancer: a systematic review and synthesis of the literature” Pain Medicine, 2013 Oct;14(10):1505-17. PMID: 23915253.
AL Bredlau, DN Korones. “Diffuse Intrinsic Pontine Gliomas: Treatments and Controversies” Adv Cancer Res 2014: 121:235-59. PMID: 24889533.
AL Bredlau, BT Harel, MP McDermott, RH Dworkin, DN Korones, JG Dolan, HR Adams. “Neurocognitive Changes after Sustained Ketamine Administration in Children with Chronic Pain” J Palliat Care Med. 2015 Mar;5(2): 215. doi:10.4172/2165-7386.1000215.
AL Bredlau, S Dixit, C Chin, AM Broome. “Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma” Current Neuropharmacology, 2016 Feb; Epub ahead of print.
AL Bredlau. “A Piece of My Mind. Where do you put the pain?” JAMA, 2016 Mar 8;315(10):983. PMID: 26954404
K Miller, S Dixit, A Moore, E McKinnon, AL Bredlau, AM Broome. “Delivery of a drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers.” Nanomedicine (Lond), 2016 Mar;11(6):581-95. doi: 10.2217/nnm.15.218.
L Kosnik Infinger, SR Karia, SL Kinsman, EJ Kosnik, CT Welsh, DR Roberts, AL Bredlau. “Subcortical DNET in a patient with an enzymatic deficiency: a rare case and review of the literature.” JPHO 2016 Nov;38(8):e291-e294.
R Metts, W Bartynski, CT Welsh, S Kinsman, AL Bredlau. “Bevacizumab therapy for Pilomyxoid Astrocytoma.” JPHO 2017; in press.
A Das, D McDonald, S Lowe, AL Bredlau, K Vanek, NL Banik, JM Jenrette III, SJ Patel, S Cheshier, R Eskandari. “Immunological low-dose radiation modulates the pediatric medulloblastoma antigens and enhances antibody-dependent cellular cytotoxicity.” Childs Nerv Syst. 2016 Dec 9; epub ahead of print.
SM Hersch, G Schifitto, D Oaks, AL Bredlau, CM Meyers, R Nahin, HD Rosas. “The CREST-E Study of Creatine for Huntington’s Disease. A Randomized Controlled Trial.” Neurology, accepted.